Amyloid Disease, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions

by Kenneth Kee

Publisher: Kenneth Kee

Publication Date: April 30, 2018

ISBN: 9780463146965

Binding: Kobo eBook

Availability: eBook

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This book describes Amyloid Disease, Diagnosis and Treatment and Related Diseases
Amyloid Disease is a progressive disease affecting the tissue infiltrates of insoluble proteins or amyloid proteins leading to poor function of the organs involved.
Amyloid Disease is a medical disorder produced by extra-cellular and or intra-cellular deposition of insoluble abnormal amyloid fibrils that alter the normal function of tissues.
In humans there are about 23 different unrelated proteins known to form amyloid fibrils in vivo.
Proteins that develop into amyloid fibrils differ in size function, amino acid effect and native structure but become non-soluble clumps that are similar in structure and in properties.
In the past amyloid disease was classified as primary amyloid disease 70% or secondary amyloid disease but with chemical testing of the amyloid protein, Amyloid is categorized chemically.
The amyloid diseases are termed with a capital A (for amyloid) accompanied by an abbreviation for the fibril protein:
1.AA amyloid disease contains a normal-sequence serum amyloid A protein
The kidneys, joints, liver and spleen are the main targets of AA amyloid deposits
2.AL amyloid Disease was previously known as primary amyloid disease
Organs involved are the heart, kidney, peripheral nerve, gastrointestinal tract, respiratory tract and nearly any other organ.
AL amyloid disease is the most frequent type of systemic amyloid disease in developed countries
3.Transthyretin amyloid disease (ATTR) is the most frequent inherited systemic type of amyloid disease
ATTR is an autosomal-dominant disease but is linked with at least 100 different transthyretin (TTR) mutations
There are many other amyloid diseases.
This disease can involve the tongue, intestines, skeletal and smooth muscles, nerves, skin, ligaments, heart, liver, spleen and kidneys